For each of the following statements, indicate if you would expect the property
ID: 91198 • Letter: F
Question
For each of the following statements, indicate if you would expect the property to be common to most lysosomal storage diseases to be true of a specific lysosomal storage disease or not to be true of any lysosomal storage diseases. A. True of most lysosomal storage diseases B. True of a specific lysosomal disorder C. Not true of any lysosomal disorder impaired metabolism of glycolipids causes mental retardation. Leads to accumulation of lysosomal degradation products in the lysosome Results from the inability to regulate the synthesis of glycosaminoglycans Triggers proliferation of organelles containing catalase. Leads to excessive amounts of glycogen in the lysosome Symptoms include muscle weakness and mental retardation Results in accumulation of lysosomes in the cellExplanation / Answer
I shall answer the first four subquestions
1. True of a specific disorder - Glycogen storage diseases
2. True of most disorders. It is because, in these set of diseases, the lysosomal function is impaired. Hence the degradation products keep accumulating in the lysosome.
3. True of a specific disorder. Mucopolysaccharidoses type 1 includes the inability to regulate the synthesis of glycosaminoglycans.
4. Not true of any disorder. Catalase helps in the breakdown of hydrogen peroxide, a potential free radical. In lysosomal storage diseases, this catalase enzyme function is deficient.
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