In mouse HindIII restriction digests, Probe AA3 picks up a simple RFLP consistin

Question

In mouse HindIII restriction digests, Probe AA3 picks up a simple RFLP consisting of two alternative alleles of 1.7kb and 3.8kb. A mouse heterozygous for the dominant allele of bent tail and the just described RFLP is mated with a wild-type mouse that shows only the 3.8kb fragment. Forty percent of the bent-tail progeny are homozygous for the 3.8kb RFLP and 60 percent are heterozygous for the 3.8kb and the 1.7kb RFLPs. A. For a mouse heterozygous for the RFLPs, diagram the relative position of the probe with respect to the HindIII restriction sites for each allele (there is more than one answer).

Explanation / Answer

ans A- as mention in the question 40% of the bent-tail progeny are homozygous for the 3.8kb RFLP and 60 % are heterozygous for the 3.8kb and the 1.7kb RFLPs and the digested DNA sample after they were separated by gel electrophoresis

The probe diagram will be-

------------|--------------------------|----------------------- 1.7kb

               |----------- probe

------------|---------------------------------------------|----------------------- 3.8kb

                               |----------- probe

                               

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