Genes contain a polyadenylation signal, a specific sequence that indicates a pol
ID: 91671 • Letter: G
Question
Genes contain a polyadenylation signal, a specific sequence that indicates a poly A tail should be added to an mRNA. Suppose a mutation occurred that altered the polyadenylation signal of a given gene and prevented the polyA polymerase from binding to the mRNA. Which of the following wound NOT be an expected consequence of such a mutation? a. Expression of the given gene is reduced. b. The mRNA is transported from the nucleus to the cytoplasm via the nuclear pore complex. c. The mRNA has reduced stability. d. All of the above would occur. Which of the following is most likely to inhibit transcription of a gene? a. A drug that binds to helicase enzyme. b. A drug that binds to the 5' cap. c. A drug that binds to the AUG start codon. d. A drug that binds to the DNA binding site of a basal transcription factor. e. A drug that binds to the small ribosomal subunit.Explanation / Answer
Que 10)
Ans:
Genes contain a polyadenylation signal, a specific sequence that indicates a poly A tail should be added to an mRNA. Suppose a mutation occurred that altered the polyadenylation signal of a given gene and prevented poly A polymerase from binding to the mRNA. The following would NOT be an expected consequence of such a mutation: b. The mRNA is transported from the nucleus to the cytoplasm via the nuclear pore complex.
Explanation:
- Mutation in polyadenylation signal of a given gene alters sequence of mRNA and may affect mRNA stability.
- Hence, the mRNA is transported from the nucleus to the cytoplasm via the nuclear pore complex would not be an expected consequence of such mutation.
Que 11)
Ans:
The following is most likely to inhibit transcription of a gene: d. A drug that binds to the DNA binding site of a basal transcription factor.
Explanation:
- RNA polymerase can attach to the promoter only with the help of proteins called basal transcription factors.
- Basal transcription factor bind to promoter and help to initiate transcription.
- Hence, a drug that binds to the DNA binding site of a basal transcription factor most likely to inhibit transcription of a gene.
Related Questions
Navigate
Integrity-first tutoring: explanations and feedback only — we do not complete graded work. Learn more.