When LDL is taken up by a cell, it will have which of the following impacts to i

Question

When LDL is taken up by a cell, it will have which of the following impacts to intracellular cholesterol?

Increase in intracellular cholesterol; Decrease on de novo cholesterol synthesis

Decrease in intracellular cholesterol; Decrease on de novo cholesterol synthesis

Increase in intracellular cholesterol; Increase on de novo cholesterol synthesis

Decrease in intracellular cholesterol; Increase on de novo cholesterol synthesis

Increase in intracellular cholesterol; Decrease on de novo cholesterol synthesis

Decrease in intracellular cholesterol; Decrease on de novo cholesterol synthesis

Increase in intracellular cholesterol; Increase on de novo cholesterol synthesis

Decrease in intracellular cholesterol; Increase on de novo cholesterol synthesis

Explanation / Answer

When LDL cholesterol is taken up by the cell, it will increase the intracellular cholesterol and decrease the de novo cholesterol synthesis. LDL is taken up into the cell by LDL receptor mediated endocytosis. This causes increase in intracellular cholesterol. This leads to decreased transcription of HMGCoA reductase gene involved in cholesterol synthesis and therefore de novo synthesis of cholesterol is decreased. Therefore, the correct answer for this question is option (a).

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