TRUE or FALSE. ______ There is a dedicated pool of ribosomes in the cytosol that

Question

TRUE or FALSE.

______ There is a dedicated pool of ribosomes in the cytosol that make cytosolic proteins and a separate dedicated pool of ribosomes for secretory proteins.

______ All GPCRs share a similar structure composed of seven transmembrane helices.

______ Components of the endomembrane system include: the ER, Golgi apparatus, lysosomes, endosomes, and the plasma membrane.

Which of the following statements about GPCRs is FALSE?

a) The G protein is inactivated when bound GTP is hydrolyzed to GDP.

b) GEF exchanges GDP for GTP activating the G protein when the signal binds to the

receptor.

c) A common effector protein activated by the G protein is adenylyl cyclase.

d) Activation of the G protein involves phosphorylation of the subunit by MAP kinase.

Explanation / Answer

1) False- There are no separate pools of ribosomes for secretory proteins and cytosolic protein. They all are made on endoplasmic reticulum and them their fate is decided by cell not the type of ribosomes from which they are translated.

2) True - all GPCR have the same serpentine structure.

3) True. - all components mentioned are part of Endomembrane system.

4) d option is false because there is no such event of phosphorylation of alpha subunit to activate G protein.

Activation of G protein involves Gdp replaced by GTP and then the G-aplha and beta-gamma complex gets separated and G protein activates.

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