Semiconductor quantum dots (QDs) have tunable fluorescence properties that have

Question

Semiconductor quantum dots (QDs) have tunable fluorescence properties that have proved useful in a wide range of applications from multiplexed analysis such as DNA detection and cell sorting and trac ing to diagnostics. You are a research scientist tasked with imaging a tumor site in a mouse. You have narrowe down your search of quantum dots to InP with the following characteristics: Before you inject your mouse with the QD solution, you give the above data to your boss who specifically states that there should be two injections, one with QDs fluorescing blue and the other red. Which range of OD sizes would you use? Someone in the chemistry department has functionalized your chosen QDs with tumor-specific molecules and you are ready to make your injections. The blue QDs are injected so as to travel at constant velocity through a continuous arteriole of diameter 2mm, and the red QDs travel at constant velocity through various channels averaging 0.50 pm in diameter. Which type of flow do the QDs feel? Assuming you have taken into account effects from the presence of red blood cells (on the order of 6-8 um), and other, smaller, molecules, and assuming the distance between the site of injection and the tumor is 5 cm, how long before you can start taking imaues of the tumor site? Blood viscosity and density are 3.5 X 10"' Pa s and 1060 kg/m^3 respectively. Blood pressure gradient is assumed constant at 1.6 X 10^9 Pa/m.

Explanation / Answer

1) 2-3 nm sized quantum dots exhibit blue color and 5-6 nm sized particle show red color.

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