(6 Points) Describe three aberrations to this pathway that could potentially lea
ID: 93219 • Letter: #
Question
(6 Points) Describe three aberrations to this pathway that could potentially lead to tumor formation. What is the consequence to the remainder of the pathway and cellular response with each aberration?
(6 Points) For one of the aberrations you listed above (let me know which you are selecting), determine a molecular target for a new cancer therapy that could correct the issue. We will assume that you are directly designing the “drug” for this therapy, so would you design an inhibitor or an activator for your molecular target? How will this help?
(8 Points) As a researcher, your job may be done at this point (after you contact a pharmaceutical company with your findings), but there are still four steps remaining in the normal process of development of new cancer therapies. Give a brief explanation of what will occur in each of the remaining steps until your drug is made available to the masses.
As a cancer research scientist, you discover a new cell signaling pathway that you believe could play a role in the development of multiple types of cancer. Below is a figure of the pathway you discovered which begins with the binding of ligand MBC493 to the extracellular domain of its receptor. Under normal circumstances, the binding of this ligand to its receptor leads to receptor dimerization and subsequent autophosphorylation. Autophosphorylation is linked to the two following pathways: One consequence of autophosphorylation is the activation of protein 1. Protein 1 has the ability to activate protein 2 (a kinase) that begins a phosphorylation cascade of proteins 3 and 4. Protein 4, upon phosphorylation, ubiquitinates protein 5. Upon the degradation of protein 5, active protein 6 is released. Protein 6 is then shuttled to the nucleus where it acts as an inhibitory factor for a series of genes that control cell proliferation. A second pathway that is activated upon ligand binding and autophosphorylation begins with protein 7. Upon activation, protein 7 activates protein 8. Protein 8 has the ability to cleave protein 9 into two segments (9a and 9b). Protein 9a, when in the presence of its activator (9a ACT), has the ability to move into the nucleus and act as a transcription factor for DNA repair genes. 9a ACT is regulated by a protein that can prevent its binding to 9a at times when DNA repair mechanisms are not needed. Protein 9b has the ability to activate DNase within the cell when it is not bound to its repressor molecule (9b REP). 9b REP is also regulated by a protein that prevents its binding to 9b when a normal cell temporarily tries to avoid apoptosis.Explanation / Answer
The aberrations that can lead to tumor formation in the pathway described are,
MBC493 receptors defect can be targeted for cancer treatment. A new drug which performs the function of MBC493 receptor; causing phosphorylation of proteins 1 and 7 can be developed for treatment of tumor resulting from this defect.
Before any new drug is made available for masses, it has to go through four phases of clinical research. They are listed below.
Related Questions
Navigate
Integrity-first tutoring: explanations and feedback only — we do not complete graded work. Learn more.