Assume all of the ionized aspirin remains in the buffer solution and all of the
ID: 934566 • Letter: A
Question
Assume all of the ionized aspirin remains in the buffer solution and all of the un-ionized aspirin goes into the ethyl acetate, what is the molar out of the aspirin in the ethyl acetate at pH 2.0 and pH 8.0?Does aspirin depend on the pH of the aqueous phase? Does 3-aminophenol depend on the pH of the aqueous phase? Does acetaminophen depend on the pH of the aqueous phase? Assume all of the ionized aspirin remains in the buffer solution and all of the un-ionized aspirin goes into the ethyl acetate, what is the molar out of the aspirin in the ethyl acetate at pH 2.0 and pH 8.0?
Does aspirin depend on the pH of the aqueous phase? Does 3-aminophenol depend on the pH of the aqueous phase? Does acetaminophen depend on the pH of the aqueous phase? Assume all of the ionized aspirin remains in the buffer solution and all of the un-ionized aspirin goes into the ethyl acetate, what is the molar out of the aspirin in the ethyl acetate at pH 2.0 and pH 8.0?
Does aspirin depend on the pH of the aqueous phase? Does 3-aminophenol depend on the pH of the aqueous phase? Does acetaminophen depend on the pH of the aqueous phase?
Does aspirin depend on the pH of the aqueous phase? Does 3-aminophenol depend on the pH of the aqueous phase? Does acetaminophen depend on the pH of the aqueous phase?
Explanation / Answer
At pH =2
The pKa of aspirin is 3.49
pH = pKa + log [Base] / [Acid]
pH = pKa + log [Ionized] / [Unionized]
2 = 3.49 + log [Ionized] / [Unionized]
log [Ionized] / [Unionized] = -1.49
[Ionized] / [Unionized] = 0.0323 /1
Total = 1 + 0.0323 = 1.0323 mol
[Un Ionized] = (1 / 1.0323 ) x 100 = 96.87 %
96.87% is present in ethyl acetate.
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At pH = 8
The pKa of aspirin is 3.49
pH = pKa + log [Base] / [Acid]
pH = pKa + log [Ionized] / [Unionized]
8 = 3.49 + log [Ionized] / [Unionized]
log [Ionized] / [Unionized] = 4.51
[Ionized] / [Unionized] = 32359.36
Total = 1 + 32359.36 = 32360.36 mol
[Un Ionized] = (1 / 32360.36 ) x 100 = 0.0031 %
0.0031% is present in ethyl acetate.
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Yes. Ionization of aspirin depends on the pH of the aqueous phase.
Yes. Ionization of 3-aminophenol depends on the pH of the aqueous phase.
Yes. Ionization of acetaminophen depends on the pH of the aqueous phase.
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