Determine whether each describes glucokinase, hexokinase or both: -phosphorylate

Question

Determine whether each describes glucokinase, hexokinase or both:

-phosphorylates hexose

-present in tissues that are less dependent on glucose for energy

-is half saturated at a concentration greater than the normal circulating blood glucose concentration

-enables the liver to buffer the blood glucose concentration

-is half saturated at much lower concentrations (0.1mM) than is its isozyme)

-not sensitive to inhibition by glucose-6-phosphate

-prevents cells from extensively phosphorylating glucose when blood glucose concentration is less than 2.5mM

-ensures that glucose generated by gluconeogenesis is not used for glycolysis in the same organ

Explanation / Answer

a) phosphorylates hexose---------> hexokinase

b) present in tissues that are less dependent on glucoke for energy------------> hexokinase

c) is half saturated at a concentration greater than normal circulating blood glucose concentration-------->glucokinase

d) enables liver to buffer blood glucose concentration--------> glucokinase

e) is half saturated at much lower concentrations(0.1mM) than is its isozyme-------> hexokinase

f) not sensitive to inhibition by glucose-6-phosphate-----------> glucokinase

g) prevents cells from extensively phosphorylating glucose when blood glucose concentration is less than 2.5mM---------> g;ucokinase

h) ensures that glucose generated by gluconeogenesis is not used for glycolysis in the same organ-------> glucokinase

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