The normal (wild-type) version of a particular protein includes a stretch of ami

Question

The normal (wild-type) version of a particular protein includes a stretch of amino acids as follows:

MET-TRP-VAL-ASP

A mutant arose in this strain as a result of treatment with a mutagen known to change, delete or add single bases.

A new amino acid sequence of the mutant is now:

MET-MET-GLY-STOP Answer the following questions by referring to the attached genetic code.

a) Show the probable sequence(s) for mRNA which codes for this sequence of amino acids in the wild-type.

b) Show the new mRNA sequence in the mutant.

c) State specifically what mutational event the mutagen caused.

Explanation / Answer

a) Probable mRNA sequence of wild type amino acid sequence: - AUG-UGG-GUU-GAU. Mutational event: addition of adenine (A) between first and second codon (between AUG and UGG). b) mRNA sequence of mutated amino acid sequence: AUG-UGG-GUU-GAU. c) Additional mutation has occurred and extra base adenine has been added between first and second codon.

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