Select the correct order of events for the signal transduction pathway initiated

Question

Select the correct order of events for the signal transduction pathway initiated by the EGF receptor.

Select the correct order of events for the signal transduction pathway initiated by the EGF receptor. Ras is phosphorylated by RAF. Glucagon binds to the receptor. An adaptor protein binds to the phosphotyrosine residues, recruiting SOS and Ras. RasGAP stimulates GTPase activity of Ras which returns to the GDP bound state. The receptor undergoes a conformational change. The Galpha subunit binds to Phospholipase C. Epidermal growth factor binds to the receptor. MEK is phosphorylated by RAF. The cytoplasmic tail of the receptor is phosphorylated. The ha subunit dissociates from Gbeta/Ggamma. MEK is phosphorylated by ERK. ERK enters the nucleus and stimulates cell proliferation. ERK is phosphorylated by MEK. The second messengers IP and DAG are produced. The receptor dimerizes activating its tyrosine kinase activity. The Galpha protein releases GDP and binds GTP.

Explanation / Answer

The correct order of events for the signal transduction pathwayinitiated by EGF receptor are listed below,

Epidermal growth factor binds to the receptor ----->

The receptor dimerizes activating its tyrosine kinase activity ----->

The cytoplasmic tail of the receptor is phosphorylated ----->

The receptor undergoes a conformational change ----->

An adaptar protein binds to phospotyrosine residues recruting SOS and Ras ----->

Ras is phosphorylated by RAF ----->

MEK is phosphorylated by RAF ----->

ERK is phosphorylated by MEK ----->

ERK enters nucleus and stimulates cell proliferation ----->

RasGAP stimulates GTPase activity of Ras which returns to the GDP bound state

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