1. The following statement is similar to those you might see on exams. Write a p
ID: 93988 • Letter: 1
Question
1. The following statement is similar to those you might see on exams. Write a paragraph of 3-5 sentences describing 1) whether the statement is correct or incorrect and 2) the reasoning for your answer. Your answer should demonstrate your understanding of the physiological concepts underlying the statement and be written professionally.
Strenuous exercise would cause a left-shift in the oxygen-hemoglobin dissociation curve. This increases the affinity of hemoglobin for oxygen and favors unloading of O2 in the tissues.
Explanation / Answer
Exercise causes an increase in acidity, temperature and metabolic intermediates and a decrease in oxygen in your muscle tissues. This causes an increased dissociation of oxygen from your blood flowing through your muscles, supplying them with much needed oxygen. Your body increases blood flow to your muscles to supply them with more oxygen.
Oxygen is required to turn fats and sugars into energy. When sufficient oxygen is not available, lactate, an intermediate product in glycolysis, the metabolic conversion of sugar into energy, builds up in your muscles. In high levels, lactate can damage your muscle cells, contributing to pain, soreness and swelling after exercise. The need to make up the extra oxygen to clear lactate from your body, excess post-exercise oxygen consumption, is thought to partially underlie the increase in metabolism following exercise.
The Bohr effect describes how the affinity of hemoglobin for oxygen changes depending on the local biochemical conditions. An increase in acidity, temperature and the concentration of intermediate chemicals in the conversion of sugar to energy—specifically 2,3-diphosphoglycerate—decreases hemoglobin's affinity for oxygen, causing oxygen to diffuse into the tissues. The local availability of oxygen also affects whether oxygen tends to bind or dissociate from hemoglobin.
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