How would the drug taxol affect the in vitro dynamic instability and treadmillin

Question

How would the drug taxol affect the in vitro dynamic instability and treadmilling experiments? Taxol would block the addition of tubulin in both experiments, leading to a destruction of the microtubules. Taxol would block catastrophe at the plus end in the dynamic instability experiment but not depolymerization at the minus end in the treadmilling experiment. Taxol would block depolymerization at the minus end in the treadmilling experiment but not catastrophe at the plus end in the dynamic instability experiment. Taxol would stabilize the microtubules in both experiments, leading to polymerization without catastrophe.

Explanation / Answer

Hi Answer:

Answer is A.

Taxol would block catastrophe at the plus end in the dynamic instability experiment but not depolymerization at the minus end in the treadmilling experiment.

Taxol prevents tubulin subunits from dissociating (blocks mitosis, used to treat cancer) and hence prevent the tumer from spreding

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