Which of the following experimental data would support the hypothesis that gap j

Question

Which of the following experimental data would support the hypothesis that gap junction function in cardiomyocytes (heart muscle cells) is dependent on the gap junction proteins being phosphorylated? Addition of kinase inhibitors to cultures of heart muscle cells results in the cells not beating together, and is correlated to cadherin proteins no longer being phosphorytated Addition of kinase inhibitors to cultures of heart muscle cells results in the cells not beating together, and is correlated to connexin proteins no longer being phosphorytated Addition of phosphatase inhibitors to cultures of heart muscle cells results in the cells not beating together, and is correlated to connexin proteins no longer being phosphorytated Addition of phosphatase inhibitors to cultures of heart muscle cells results in the cells not beating together, and is correlated to claudin proteins no longer being phosphorytated

Explanation / Answer

Addition of kinase inhibitors to cultures of heart muscle cells results in muscles not beating together, and is correlated to connexin proteins no longer being phosphorylated is the correct answer as gap junctions(composed of connexin) are needed to be phosphorylated by tyrosine kinanes inhibited in this case.

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