Which of the following statements is not correct? A. A highly penetrant disease

Question

Which of the following statements is not correct? A. A highly penetrant disease means that the majority of patients carry the disease allele of interest. B. Expressivity means that different alleles of one gene will show different degrees of a phenotype. C. Both penetrated and expressivity could be due to the environmental impacts on genes and the gene-gene interactions ( in other words, genetic backgrounds). D. Lethality is caused by the mutation in the essential genes. Which of the following statements is not correct? A. A highly penetrant disease means that the majority of patients carry the disease allele of interest. B. Expressivity means that different alleles of one gene will show different degrees of a phenotype. C. Both penetrated and expressivity could be due to the environmental impacts on genes and the gene-gene interactions ( in other words, genetic backgrounds). D. Lethality is caused by the mutation in the essential genes. A. A highly penetrant disease means that the majority of patients carry the disease allele of interest. B. Expressivity means that different alleles of one gene will show different degrees of a phenotype. C. Both penetrated and expressivity could be due to the environmental impacts on genes and the gene-gene interactions ( in other words, genetic backgrounds). D. Lethality is caused by the mutation in the essential genes.

Explanation / Answer

B is not correct because expressivity means that same allele of one gene will show different degrees of a phenotype. Like gene involved in quantitative trait like body weight can have large variance in the weight of individuals from the same allele. And this can be modified by other gene gene interactions and different environmental factors.

Option A C and D are correct.

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