Describe the role of the following amino acids (based upon the picture and the r

Question

Describe the role of the following amino acids (based upon the picture and the reaction steps)

Asp 176

His 263

Ser 152

Phe 77

Leu 153

ASP176 Asp178 O- H His203 His263 Ser152 Ser152 -R Phe77-N Phenn Leu15s Phen" Leu153 Step 1 Asp176 Asp176 O- H His203 N His263 Ser152 Ser152 R. a Phen" N Leu,53 Phe77-N Phe77R Lou153 Step 2 Asp176 ASP176 N His263 His263 Ser152 Ser 152 Pherr-N Leu153 Phe77-N Leu163 R Leu159 Step 3 Asp176 Asp178 His263 His263 Ser 152 Ser152 Ser152 Phe77-N Leu153 Phezz-N Phe77 . R Leu153 Step 4 /O

Explanation / Answer

The role of amino acids are,

Asp 176 does not play any active role in mechanism

His 263 acts as an acid-base catalyst

Ser 152 acts as a activator of C=O functionality

Phe 77 does not play any active role in mechaism

Leu 153 does not play any active role in mechanism

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