A 60-year-old male with chronic obstructive pulmonary disease undergoes a lung t

Question

A 60-year-old male with chronic obstructive pulmonary disease undergoes a lung transplant. Immunohistochemical staining of his lung specimen reveals reduced expression of secretory component in the epithelial cells of his small airways. These findings indicate a likely impairment in which process in the lung of this patient before surgery? A. Leukocyte homing in response to infection B. Secretion of mucus C. Assembly of the membrane attack complex D. Formation of multimeric immunoglobulin molecules E. IgA passage through the mucosal epithelium

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Answer:

Q: A 60 year old male with chronic obstructive pulmonary disease undergoes a lung transplant. Immunohistochemical staining of his lung specimen reveals reduced expression of secretory components in the epithelial cells of his small airways. These findings indicate a likely impairment in which process in the lung of this patient before surgery?

A) Leukocyte homing in response to infection

B) Secretion of mucus

C) Assembly of the membrane attack complex

D) Formation of multimeric immunoglobulin molecules

E) IgA passage through the mucosal epithelium - Correct Answer (the reduction of bronchial secretory IgA correlates with chronic pulmonary obstructive disease)

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