the reaction can be done with simple carbonyl compounds like acetone or 1,3 dica

Question

the reaction can be done with simple carbonyl compounds like acetone or 1,3 dicarbonyls like acetylacetonde. the conditions for the reactions and the limitations Upton them are quite different. what can you say about those conditions? What bases can be used to deprotonate the compounds and what the structure of R can be?

6) (8 points) alkylation reacions of cater compounds are important C-C bend fonning reacions that we discuss in detail later in the semester, but they can be sussmarieed with the folowing scheme. Base R-LG LG means leaving goup, end the R and i' proups can b means Seerving group, end the R and r' groups can ba pretty much anyching thit Ive vet a C miaking the b

Explanation / Answer

(a): We can use strong bases like C2H5ONa/C2H5OH, lithium diisopropylamide(LDA), NaH etc. to deprotonate.

(b): The reaction of R' - LG with the deprotonated carbonyl compound proceeds via SN2 mechanism. Hence only primary alkyl halide, allyl halide and benzyl halide favor the reaction. Hence the structure of R should be primary, allyl or benzyl group.

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