How is the type of feedback inhibition known as enzyme multiplicity correctly de

Question

How is the type of feedback inhibition known as enzyme multiplicity correctly described? a. Different isozymes in a pathway are independently controlled by different modulators: this prevents one biosynthetic product from shutting down key steps in a pathway when other products of the same pathway are needed. b. A metabolite inhibits its own formation at several different points with multiple, overlapping inhibition in the synthetic pathway. c. Metabolite synthesis is inhibited at one enzymatic point by more than one end product of its own metabolism: effects of different inhibitors on the enzyme are more than additive, and all the inhibitors together more or less shut down the enzyme. d. Enzyme multiplicity refers to an enzyme cascade that results in the covalent modification of a key regulatory enzyme. e. All of the above are true. Metabolism is often regulated by: a. Allosteric effectors, covalent modification, enzyme sequestration, protein association, enzyme synthesis, enzyme degradation, temperature change, and pH change. b. Allosteric effectors, covalent modification, enzyme sequestration, protein association, enzyme synthesis, enzyme degradation, and pH change. c. Allosteric effectors, covalent modification, enzyme sequestration, protein association, enzyme synthesis, and enzyme degradation. d. Allosteric effectors, covalent modification, protein association, enzyme synthesis, enzyme degradation, temperature change, and pH change. e. Allosteric effectors, covalent modification, enzyme synthesis, enzyme degradation, and temperature change. Choose the answer that best describes regulatory enzymes. a. Regulatory enzymes are typically composed of multiple subunits. b. Regulatory enzymes often catalyze the first committed reaction of a pathway. c. Regulatory enzymes often display sigmoidal kinetics. d. Regulatory enzymes can be activated and inhibited by allosteric and/or covalent means. e. As opposed to non-regulatory enzymes, will operate at various speeds depending on their regulatory status. f. All of the above are true.

Explanation / Answer

ANSWER:

1) Metabolite synthesis is inhibited at one enzymatic point by more than one product of its own metabolism,effects of different inhibitors on the enzyme are more than additive ,and all the inhibitors together more or less shut downn the enzyme.

2) Allosteric effectors,covalent modification,enzyme sequestration,protein association,enzyme synthesis,enzyme degradation,temperature change,and pH change.

3) Regulatory enzymes can be activated and inhibited by allosteric and /or covalent means.

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