(12) Which of the following evidence can show that a candidate gene is a human d
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(12) Which of the following evidence can show that a candidate gene is a human disease gene? A) Showing that the gene is regulated in the cells impacted by the disease B) Replacing the orthologous gene in mouse with either the human disease allele or the knockout version of the gene causes a similar disease phenotype. C) Both A and B D) None of the above (13) In generating knockout mice, what is the purpose of the double selections using NEO and TK genes? A) Making sure homologous recombination to occur so that the wild-type gene can be replaced. B) Making sure random integration does not happen in transformed cells C) Making the selection of transformants much easier D) A and B E) A and C F) All of the above (14) Analogous to the genetic code, the particular constellation of biochemical modifications to histone tails that dictates a particular chromatin state is dubbed the A) Protein code B) Post-translational code C) Amino acid code D) Histone code E) None of the aboveExplanation / Answer
`12. (C) Both A and B
13. (E) A and C
14. (D) constellation of biochemical moifications to histone tails that dictates a particula chromatin state is dubbed the Histone code
9. D) All carpels
10. C) This gene acts as a negative regulator in normal glucose response
11. A) A foreign DNA that has been transferred from one organism to another
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