Two proteins are being proposed as novel metabolic cancer targets. One target is

Question

Two proteins are being proposed as novel metabolic cancer targets. One target is a lactic acid transporter called MCT1. The other target is an enzyme complex called the pyruvate dehydrogenase (PDH) complex. The PDH complex catalyzes the conversion of pyruvate to acetyl-CoA: The Results from biological testing of cancerous tumors suggest that under aerobic and anaerobic conditions, extracellular lactate levels correlate with cancer aggressiveness and resistance to chemotherapy. Clinical results further indicate differential up-regulation of MCT1 and down-regulation of MCT4 (another lactate transporter) on aggressive and treatment-resistant tumors. Preliminary pre-clinical results from healthy mice suggest MCT4 knockouts (but not MCT1 knockouts) are lethal. Based on the two proposed targets and the evidence provided, what type of drug should be developed? Please circle the correct answer. a.PDH inhibitor b. MCT1 and MCT4 inhibitors c. MCT1 inhibitor d. MCT4 inhibitor.

subject: computitional biochemistry

Explanation / Answer

a)PDH inhibitor

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