During DNA replication, which of the following would you expect to be true? True

Question

During DNA replication, which of the following would you expect to be true?
True or False: and why.

1. More ligase would be associated with the lagging strand than with the leading strand.
2. More primase would be associated with the lagging strand than with the leading strand.
3. More helicase would be associated with the lagging strand than with the leading strand.
4. DNA ligase links the 3' end of one Okazaki fragment to the 5' end of another Okazaki fragment in the lagging strand.
5. In the lagging strand, the enzyme DNA polymerase III that produces the next Okazaki fragment also removes the short segment of primer RNA on the previous Okazaki fragment.

Explanation / Answer

1. More ligase would be associated with the lagging strand than with the leading strand.-TRUE-Because many more nicks will be present between okazaki fragments in the lagging strand.
2. More primase would be associated with the lagging strand than with the leading strand. -TRUE-because many primers are needed to synthesize short strands of DNA called Okazaki fragments.
3. More helicase would be associated with the lagging strand than with the leading strand.-FALSE-Helicase is used to open up DNA helix for replication. There is no difference in strands for activity for helicase
4. DNA ligase links the 3' end of one Okazaki fragment to the 5' end of another Okazaki fragment in the lagging strand.-TRUE-When primers are removed, DNA polymerase fills in the gaps. These extended okazaki fragments are then linked by DNA ligase.
5. In the lagging strand, the enzyme DNA polymerase III that produces the next Okazaki fragment also removes the short segment of primer RNA on the previous Okazaki fragment-FALSE-DNA polymerase I removes the primers.

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