How is the type of feedback inhibition known as enzyme multiplicity correctly de

Question

How is the type of feedback inhibition known as enzyme multiplicity correctly described?

a. Different isozymes in a pathway are independently controlled by different modulators; this prevents one biosynthetic product from shutting down key steps in a pathway when other products of the same pathway are needed. b. A metabolite inhibits its own formation at several different points with multiple, overlapping inhibition in the synthetic pathway. c. Metabolite synthesis is inhibited at one enzymatic point by more than one end product of its own metabolism; effects of different inhibitors on the enzyme are more than additive, and all the inhibitors together more or less shut down the enzyme. d. Enzyme multiplicity refers to an enzyme cascade that results in the covalent modification of a key regulatory enzyme. e. All of the above are true.

Explanation / Answer

The presence of several different isoforms of the enzyme to catalyse the same reaction is called as enzyme multiplicity. The isoforms of the enzymes have different regulations and these isoforms are expressed or active under several different conditions. Enzyme multiplicity helps in fine tuning of the complex regulatory signals and it ensures that the presence of one inhibitor cannot knockdown the entire biosynthetic pathway. Therefore, the answer for this question is option a.

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