1)Telomere shortening, which leads to replicative senescence in cells, is a resu
ID: 96741 • Letter: 1
Question
1)Telomere shortening, which leads to replicative senescence in cells, is a result of:
excessive endonuclease activity in the cell.
telomerase activity.
the inability of DNA polymerase to replicate the very ends of the chromosomes occupied by the RNA primer, and the absence of telomerase in "normal" cells.
replication error.
A)excessive endonuclease activity in the cell.
B)telomerase activity.
C)the inability of DNA polymerase to replicate the very ends of the chromosomes occupied by the RNA primer, and the absence of telomerase in "normal" cells.
D)replication error.
Explanation / Answer
Telomeres are distinctive structures present at the end of DNAs. The sequence TTAGGG is repeated over and over again. Telomeres help in protecting the ends of chromosomes by forming a cap. Telomeres are protected from shortening by the action of enzyme telomerase. But, due to ageing telomere shortening takes place. It is due to the insbility of DNA polymerase to replicate the very ends of the chromosomes occupied by the RNA primer and the absence of telomerase in normal cells. Therefore, the answer for this question is option c.
Telomerase activity maintains the length of telomeres. Replication error causes mutation.
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