Which of the following is TRUE of glutamate dehydrogenase (GDH)? GDH catalyzes t

Question

Which of the following is TRUE of glutamate dehydrogenase (GDH)? GDH catalyzes the formation of ammonia destined for the Urea Cycle. GDH is a cytoplasmic enzyme that binds to the outer surface of mitochondria. GDH uses NAD in reductive amination of alpha-ketoglutarate. GDH is regulated by arginine and N-acetylglutamate. GDH undergoes enzyme-catalyzed adenylylation and deadenylylation. Which of the following statements is TRUE? Excess ammonia depletes alpha-keto-glutarate. Excess ammonia lowers the pH, resulting in reduced rates of glycolysis. Excess ammonia lowers mitochondrial pH. Excess ammonia improves phosphate uptake by mitochondria. Excess ammonia is rarely toxic to humans.

Explanation / Answer

Question 45: The enzyme GDH is present in the mitochondria.

The L-Glutamate is converted into alpha-ketoglutarate and ammonia by the enzyme GDH. The ammonia production is high by the GDH causes toxic effects in cell. The excesses ammonia can be removed by urea cycle.

Hence, the option (1) is the correct answer.

QUESTION-46:

The excess ammonia is called hyperammonia.

The excess ammonia leads to liver failure because the excess ammonia mainly causes depletion of alpha ketoglutarat and it leading to the stoppage of TCA cycle.

Hence, option (1) is the correct answer.

Related Questions

Navigate

• Browse (All)
• Browse W
• Subjects

---

---

Integrity-first tutoring: explanations and feedback only — we do not complete graded work. Learn more.