Which of the following is evidence that proteoglycans mediate cell growth proces

Question

Which of the following is evidence that proteoglycans mediate cell growth processes?

A] Heparin and heparin sulfate are known to inhibit cell proliferation in a process involving internalization of the glycosaminoglycan moiety and its migration to the cell nucleus.
B] Fibroblast growth factor binds tightly to heparin and the heparin-growth factor complex protects the growth factor from degradative enzymes.
C] Transforming growth factor has been shown to stimulate the synthesis and secretion of proteoglycans in certain cells.
D] Several proteoglycan core proteins have domains similar in sequence to those of epidermal growth factor.

Choose the correct answer:

Explanation / Answer

Proteoglycans mediate cell growth processes are evident from all the processes mentioned above.

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