Cholera is a dangerous disease caused by a bacterium, Vibrio cholerae, which sec

Question

Cholera is a dangerous disease caused by a bacterium, Vibrio cholerae, which secretes a toxin. This toxin has all of the following properties except Cholera toxin cleaves ATP and transfers the rbose-5-phosphate groups to other proteins Cholera toxin ADP-ribosylates the G_ alpha s subunit of heterotrimeric G proteins, thereby inhibiting their GTPase activity Cholera toxin increases the concentration of cAMP and activation of protein kinase A An overactive Protein kinase A phosphorylates the CFTR (cystic fibrosis transmembrane conductance regulator) chloride channel so that it remains permanently open

Explanation / Answer

The vibrio cholerae toxin have all the properties except this property that cholerae toxin cleavage ATP and transfer the ribose-5-phosphate group to other proteins.

Instead ot cleavage ATP, cholerae toxin triggers indocytosis through the pentameric GM1 ganglioside receptor on the intestine cell.

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