Two drug candidates with similar chemistry but somewhat different PK/PD paramete

Question

Two drug candidates with similar chemistry but somewhat different PK/PD parameters are under consideration. The drug response correlates with AUC after a single dose as illustrated below and reported in the table that follows. Which drug candidate has a higher potency? Which drug candidate has a higher efficacy? Both drugs are metabolized and excreted according to first-order kinetics. Drug A has a plasma half-life of 7.0 h and Drug B a plasma half-life of 1.0 h. Which drug candidate is more rapidly metabolized? For each drug, estimate the single dose required (mg/kg) to achieve an effective response in 90% of the population assuming rapid absorption and distribution of the single dose with metabolism as given in part (c). Assume a specific volume of distribution of 0.6 1/kg.

Explanation / Answer

Answer: According to the given informations , Here [a] the candidate A has higher potency level and the candidate B has a higher efficacy . [b] The metabolized is a slow process which consume a time and hence wich has high half life time period is more rapidly metabolized so the drug A is more rapid metabolizerd .

Hecne this is all about the given questions Thank you :)

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