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Consider the explanations (below) as to \"Why uracil is retained in RNA but not

ID: 98450 • Letter: C

Question


Consider the explanations (below) as to "Why uracil is retained in RNA but not DNA?" Which explanation is FALSE? a. Cytosine can spontaneously turn into uracil, through a process called hydrolytic deamination. b. Cells have a DNA repair system that can detect when a uracil is sitting where a cytosine should be, and correct the mistake before it is replicated and passed on. c. Before uracil can be incorporated into DNA, it is chaperoned to the TCA cycle and used to generate FADH_2. These particular chaperones are not found in the cytoplasm so they do not prevent uracil from becoming part of RNA molecules. d. RNA is more short-lived than DNA and - with a few exceptions - is not the repository for long-term storage of genetic information, so cytosine molecules that spontaneously turn into uracils in RNA do not present a great threat to the cell. e. There was probably no evolutionary pressure to replace uracil with the more complex (and presumably more costly) thymine in RNA.

Explanation / Answer

The given explanation"Before Uracil can be incorporated in to DNA, it is chaperoned to the TCA cycle and used to generate FADH2. These particular chaperones are not found in the cytoplasm so they donot prevent uracil from becoming part of RNA molecules" (option-C) is clearly FALSE and is not the reason for why uracil is retained in RNA but not DNA. The remaining explanations are true and indicates the exact reason.

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