Aspartic acid residues resemble phosphorylated serine residues in proteins and a

Question

Aspartic acid residues resemble phosphorylated serine residues in proteins and also carry a similar negative charge. As a result, a protein in which serine residues are mutated to aspartic acid residues may mimic the function of the corresponding wild-type protein when those serines are phosphorylated. Given that phosphorylation on serine residues in a number of Golgi matrix proteins occurs during mitosis, would you expect that mutation of these serines to aspartic acids would prevent Golgi stack formation in interphase or prevent Golgi dispersion in mitosis?

Explanation / Answer

Ans- the phosphorylation of amino acids to convert into the another amino acid like from Serine to aspartic acid is called phosphomimics. These phosphomimics are known to increase the golgi processes and they have no inhibitory effect on the golgi stack formation or golgi dispersion in mitosis but increase the working capacity of golgi apparatus.

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