Organic require many differential small molecules for their moment-to-moment act

Question

Organic require many differential small molecules for their moment-to-moment activities. These small molecules are often produced in enzymatic pathway that have three or more enzymes making modifications to the substrate. These pathways must be regulated to the small molecules are present in appropriate amounts. The image shown is hypothetical enzymatic pathway with five enzymes, labeled E_1, E_2, E_3, E_4, and E_5. The enzymes make products, labeled P_0, P_1, P_2, P_3, P_4, and P_5. Which of the following statements is most likely to be true in the case of the feedback regulated enzymatic pathway shown? P_0 binds E_5 and activate it. P_2 binds E_2 and activate it. P_3 binds E_1 and activate it. P_4 binds E_3 and activate it. P_5 binds E_4 and activate it.

Explanation / Answer

Feedback inhibition is a form of allosteric regulation in which the final product of a sequence of enzymatic reactions accumulates in abundance. With too much of this product produced, the final product binds to an allosteric site on the first enzyme in the series of reactions to inhibit its activity.

so P5 is the final product here and it will inhibit E1 activity

option 3

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