Cancer can be defined as an abnormal proliferation of cells that the normal regu

Question

Cancer can be defined as an abnormal proliferation of cells that the normal regulatory controls observed by the normal cells. Recently, histone deacetylation therapies have been attempted in treatment of certain cancers (reviewed by Delcuve et al., ). Specifically, the FDA has approved histone deacetylation) inhibitors for the treatment of cutaneous T-cell Histone hyperacetylation (overacetylation) of certain genes is associated with cancer. What is the effect of histone acetylation on gene expression, and what is the normal function of the genes affected? decreased expression of anti-division genes increased expression of anti-division genes decreased expression of pro-division genes increased expression of pro-division genes

Explanation / Answer

Ans. Due to histone acetylation of gene expression, DNA would be more accesible and as a result of which the transcription factors would be able to reach the DNA. The transcription activation would takes place due to acetylation of histones leading to increased expression of genes.

Hence the correct option would be option D which is increased expression of pro division genes.

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