Predict the major product of the following reaction: predict the product of the

Q: Predict the major product of the following reaction: predict the product of the

2. since LDA is strong base alkylation will takes place at sterically less hindered side so option D is correct answer 3. this alkylation of active methylene group followed by hydrolysis of ester and decarboxylation option D is the correct answer 4 this is a bayervilliger oxidation alkyl group will migrate much quicker than hydrogen so option D is the correct answer 5 remaining questions are too small i cant even read those questions

ID: 1004237 • Letter: P

Question

Predict the major product of the following reaction: predict the product of the following reaction: predict the product of the following reaction: acid chlorides (and thioesters like acetyl coenzyme A) react faster than normal esters with nucleophiles, like in base-catalysis hydrolysis. Why? Pick the one best answer, with statements that are all true and relevant to the question. The C-CI distance in the acid chloride is longer than the C_O distance in the ester, leading to poorer orbital overlap between the 3p the acid chloride carberryl group is less sterically hindered and easier to actcak. The rate-determining step for the reaction of the ester is less uphill and slower. The 3p orbital on CI is larger than the 2p orbitals of the c_O pi bond leading to a mismatch in orbital sizes and poorer orbitals overlap between the 3p and C-O pi orbital in the acid chloride, causing it to be less stable and more reaction toward nucleophiles. Inductive effects make the ion formed from the acid chloride more stable than for the ester. The alternate resceance form makes the ester more stabilized than the acid chloride, making the addition reaction step for the acid chloride less uphill and faster because it loses less resonance stabilization as it goes to the transition state for addition. A combination of D and F. A combination of A and B and C. A combination of C and E. A combination of A and D and F. A combination of B and D and F. A combination of C and E and F. A combination of A and C and F.

Explanation / Answer

since LDA is strong base alkylation will takes place at sterically less hindered side

so option D is correct answer

this alkylation of active methylene group followed by hydrolysis of ester and decarboxylation

option D is the correct answer

this is a bayervilliger oxidation

alkyl group will migrate much quicker than hydrogen so

option D is the correct answer

remaining questions are too small i cant even read those questions

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Predict the major product of the following reaction: predict the product of the

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