Oral administration of S-adenosylmethionine has been reported to be effective in

Question

Oral administration of S-adenosylmethionine has been reported to be effective in treating depression. Suggest a possible explanation.

Select all that apply.

Select all that apply.

AdoMet could partly compensate for B12 insufficiency. AdoMet could affect membrane fluidity through effects on phospholipid metabolism. If AdoMet could cross the blood-brain barrier, it might conceivably increase methylation of norepinephrine to give epinephrine. AdoMet could activate the redox-chain components, enhancing cell-respiration processes. AdoMet could act through folate metabolism, increasing the pool of labile methyl groups.

Explanation / Answer

Answer:

Oral administration of S-adenosylmethionine has been reported to be effective in treating depression due to following reasons:

b. AdoMet could affect membrane fluidity through effects on phospholipid metabolism.

c. If AdoMet could cross the blood-brain barrier, it might conceivably increase methylation of norepinephrine to give epinephrine.

Explaination:

b. AdoMet could affect membrane fluidity through effects on phospholipid metabolism.

S-adenosylmethionine (Adomet) is a naturrally occuring occuring compound found in almost every tissue and fluid in the body. The most important reaction of Adomet reaction involves the biosynthesis and methylation of phospholipids which leads to maintain membrane fluidity. Adomet administration thus protect from reduction in membrane fluidity.

c. If AdoMet could cross the blood-brain barrier, it might conceivably increase methylation of norepinephrine to give epinephrine.

As a methyl donor in the brain, SAMe is involved in the synthesis of neurotransmitters such as norepinephrine, dopamine and serotonin. SAMe is also ivolved in the production of other important brain chemicals such as hormones, nucleic acids, proteins and phospholipids. the S-adenosylmethionine used as a cofactor to convert norepinephrine to epinephrine. SAMe (Adomet) is capable of crossing the blood brain barrier and work by enabling the body to make more of the neurotransmitters directly within the brain.

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