Assume that the binding of one molecule of epinephrine to a seven-transmembrane

Question

Assume that the binding of one molecule of epinephrine to a seven-transmembrane helix (7TM) receptor (also called the G protein-coupled receptor, or GPCR) results in the activation of 190 G subunits. In addition, suppose that each activated adenylyl cyclase catalyzes the conversion of 40 ATP molecules to cAMP per second. (Assume that each G protein activates a single unique adenylyl cyclase.) Calculate the number of moles of cAMP that are produced per second. Enter your answer to at least two significant figures.

Explanation / Answer

Given that each G protein activates a single unique adenylyl cyclase.

Hence 190 G will activate 190 unique adenylyl cyclase.

also given each activated adenylyl cyclase catalyzes the conversion of 40 ATP molecules to cAMP per second

number of moles of cAMP that are produced per second = 190 x 40 = 7600 cAMP / sec

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