Assume that the binding of one molecule of epinephrine to a seven-transmembrane

Question

Assume that the binding of one molecule of epinephrine to a seven-transmembrane helix (7TM) receptor (also called the G protein-coupled receptor, or GPCR) results in the activation of 220 G subunits. In addition, suppose that each activated adenylyl cyclase catalyzes the conversion of 20 ATP molecules to cAMP per second. (Assume that each G protein activates a single unique adenylyl cyclase.) Calculate the number of moles of cAMP that are produced per second. Enter your answer to at least two significant figures.

Explanation / Answer

Just simple calculations, first, calculate the number of molecules per second:

220 x 20 = 4400 molecules/s.

to get the number of moles, just divide between avogadro number so:

(4400 molecules/s) x (1 mol/ 6.022x1023) = 7.3065x10-21 moles/s

rounded to 2 sig figs: 7.3x10-21 moles/s

Hope this helps

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