Two compounds are to be separated by liquid-liquid extraction which have identic

Question

Two compounds are to be separated by liquid-liquid extraction which have identical partition coefficients, K_p = 4.0, Compound A, however, is a weak, neutral acid, pK_a = 4.0, such that its distribution ratio, D_C, may be perturbed by adjusting the pH of the aqueous phase. What must the pH of the aqueous phase be in order for D _c = 0.25 (b) Given the two compounds above with D_c = 0.25 and 4.0, respectively. calculate and plot the solute fraction for both compounds in the first 5 tubes of a Craig extractor after 4 equilibrium and transfer steps. Assume equal volumes of organic and aqueous phases (D_c = D_m).

Explanation / Answer

Answe

Therefore, log(4.0/0.25 -1) = pH - 4.0

1.176 = pH - 4.0

pH = 1.176 + 4.0 = 5.176

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