HEM 104 Homework 5 15 points-Ch. 17.6,18.3-4 Hemoglobin (Hb) is the main oxygen
ID: 1024936 • Letter: H
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HEM 104 Homework 5 15 points-Ch. 17.6,18.3-4 Hemoglobin (Hb) is the main oxygen transport protein in the blood. Each hemoglobin molecule can transport four oxygen atoms at a time, one at each of its four iron-based binding sites. The binding of O2 to hemoglobin is a pH-dependent equilibrium, simplified as: 6. Use Le Chatelier's Principle to answer the following questions: a) What form of hemoglobin, HbHa or Hb(02)4, would be favored in the lungs? What form would be favored in the cells to which oxygen is transported? Explain in 2-4 sentences. When a person hyperventilates, the CO2 concentration in the blood is decreased. How would this affect the oxygen-binding equilibrium of hemoglobin? (Hint: remember the relationship between CO2 concentration and pH from Problem 5!) How does breathing into a paper bag help to counteract the effects of hyperventilation? When a person suffers a cardiac arrest, CO2 builds up in the blood. Patients in this situation are sometimes given an injection of 5% sodium bicarbonate (NaHCO3) solution, why is this treatment necessary? Explain b) c) d)Explanation / Answer
a) Inhaled oxygen needs to be moved from lungs to blood to body cells.So to transport Oxygen HbH44+ form of haemoglobin would be need to bind O2 and carry to cells.At cells O2 needs to be released in the cells for metabolic activities.So to unbind O2 from haemoglobin more of Hb(O2)4 form would be required to move the given reaction in backward direction to attain equilibriumas Hb(O2)4 is to be reduced.
b)When a person hyperventilates a disbalance occurs in the exchange of O2 and CO2.More of CO2 is exhaled than the O2 is inhaled.As a result blood CO2 level decreases and pH of blood increases that is [H+](H+ concentration) in blood decreases. So with decrease in H+ concentration, according to Le Chateliers principle reaction equilibrium will to counter H+ concentration decrease, and thus reaction equilibrium will shift towards right, that is product side and will try to decrease pH and as a result create more of Hb(O2)4.
c)The CO2 released into the bag is taken back again during inhalation from the bag and thus tries to maintain blood CO2 level countering the effect of hyperventilation.
d)Because of CO2 build up pH decreases(acidosis occurs).In this scenario injecting NaHCO3 leads to improving blood buffering capacity to counter lowering blood pH.
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