Please help myloid fibrils are associated with man iseases liseases such as scr

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myloid fibrils are associated with man iseases liseases such as scr or n and e es oltre, Human dseasecharacterzed by armyoid ftbris hckude Alzhelmer's he images below apie in sheep and bovine spongiform encephalitis (BSE, or mad cow disease) have show a short segment of a typical amyloid fibril. The image on the left shows the side hains protruding from the faces of the p-sheets. Choose the true statements about amyloid fibrils. An amyloid fibri, is stabilized by hydrophobic interactions between aromatic residues. Proteins that convert to an amyloid fibril structure tend to have low solubility in their native form. Soluble proteins that misfold and form amyloid fibris become insoluble. Because most newly synthesized proteins fold correctly, the accumulation of misfolded An amyloid fibril typically forms from aggregates of misfolded peptides resulting from L proteins for fragments) tends to occur slowly, thus explaining the slow onset of disease. frameshift mutations

Explanation / Answer

Correct statements – 1,3,4

1)

Reduction of hydrophobicity and intrinsic ?-sheet tendency are the main key factors to decrease aggregation rate of the amyloid fibrils. The aggregation of aromatic residues is mainly depends on these factors rather than their aromaticity.

3),4)

Amyloid refers to the abnormal deposits of extracellular, proteinaceous fibrous substance, which is normally found in organs and tissues, and caused diseases. Soluble proteins are assembled to form insoluble fibers. Misfolded proteins are aggregated slowly to form fibrils, and become insoluble, therefore explaining the slow onset of disease.

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