What kinds of amino acid side chains would probably be present at the binding si

Question

What kinds of amino acid side chains would probably be present at the binding site for GTP in this form to interact with the various parts of the GTP molecule? Without looki0ng at the PowerPoint slide showing the three views of cross linked taxol (tacotere) bound to0 tubulin, what kinds of amino acid side chains would probably be present at the binding site for taxol (structure on next page) to interact with the various parts of the taxol molecule? Do look at the tubulin slide to observe how taxol seems to bind. For slides 6, 7, 8, and 9, describe what is happening experimentally and what purification or observation is accomplished in each case. The captions associated with each figure (figures 2, 3, 4 and 5) in the paper and the Materials and Methods section will help you with this. What is the importance and significance of the work reported in this paper?

Explanation / Answer

Binding site amino acids

(i) type of amino acids present at the bindng site of GTP are polar amino acids that can form strong hydrogen bonds with the structure.

(ii) Type of amino acid present in taxol v=binding site are polar acidic amino acids. Amino acids which can form strong intermolceulcar hydrogen bonds between the taxol are the ones which are present in the structure.

(W. Significance of the work : The work decsirbes in detail the acitive site of taxol and its mode of action by interaction with the amino acid part of the binding site. The strength of binding at the location and the functions thereoff is shown in detail.

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