All amino acids have two ionizable functional groups: an ?-amino group (average

Question

All amino acids have two ionizable functional groups: an ?-amino group (average pKa of 9.4) and an ?-carboxylic acid group (average pKa of 2.2). Arginine also has an ionizable side chain (R group) with a pKa of ~12.5. One of the possible ionization states of arginine is shown below. Please help! Thank you!

Map Sapling Learning macmillan learning amino acids have two ionizable functional groups: an a-amino group (average pKa of9.4)and an a carboxylic acid group (average pKa of 2.2). Arginine also has an ionizable side chain (R group) with a pKa of-12.5. One of the possible ionization states of arginine is shown below. H3N CH-C OH CH CH CH NH NH NH At what pH would the above structure be the predominant ionization state? Note: Consider the ionization state of all three of the functional groups. pH Select answer Scroll down for more of this question. Previous 3 Give Up & View solution Check Answer 0 Exit Next B Hint

Explanation / Answer

Pka of carboxylic acid is 2.2 which is least out of thtee

even that is also protonated means

pH at less than 2.2 the above ionization state is predominent

answer is less than 2.2

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