Some enzymes adjust significantly to their substrates (an induced fit), while ot

Question

Some enzymes adjust significantly to their substrates (an induced fit), while others are more rigid and are better examples of the older lock-and-key model. Explain in the context of enzymes that are promiscuous versus enzymes that have high specificity why these differences exist. There are proteases in the blood (pH 7.4), in the duodenum (pH ~8), in the stomach (pH ~ 2) and, in the lysosomes of cells (pH ~4). Make a guess about the optimum pH that might be observed for each of these enzymes and explain your guess.

Explanation / Answer

(3)The ability of an enzyme to catalyse a fortuitous side reaction in addition to its main reaction is called the enzyme promiscousity. Normally enzymes act as catalysts to metabolism. Although they are specific catalyst they perform certain side reactions also. These promiscous activities are relatively slow compared to their main native activities.But there are some enzymes which process only a certain specific function.processes such as inflammation, metabolism, apoptosis there are some soecific enzymes as they are very very importaant protein systhesis reactions in body.That is why promiscous and specificity present.

(4)pH=7.2 because most of the enzymes in human body function in this range. but there are some exceptions also.Because 7.2 is the pH of most of the body fluids.

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