Which of the following statements is true about the regulation of the PDH comple

Question

Which of the following statements is true about the regulation of the PDH complex? A.) PDH kinase participates in positive allosteric regulation
B.) magnesium and calcium ions are positive allosteric regulators of the PDH kinase
C.) non- acetylated co-A and NAD+ are negative heterotrophic allosteric regulators
D.) none of these are correct
Please explain your answer Which of the following statements is true about the regulation of the PDH complex? A.) PDH kinase participates in positive allosteric regulation
B.) magnesium and calcium ions are positive allosteric regulators of the PDH kinase
C.) non- acetylated co-A and NAD+ are negative heterotrophic allosteric regulators
D.) none of these are correct
Please explain your answer A.) PDH kinase participates in positive allosteric regulation
B.) magnesium and calcium ions are positive allosteric regulators of the PDH kinase
C.) non- acetylated co-A and NAD+ are negative heterotrophic allosteric regulators
D.) none of these are correct
Please explain your answer

Explanation / Answer

The option A is true because the activity of PDH kinase is enhanced when the level of ATP, NADH and acetyl-CoA increases. Further, NADH and Acetyl co-A are positive allosteric regulators of the PDH kinase and, non- acetylated co-A and NAD+ are positive heterotrophic allosteric regulators .of PDH complex ruling out the options B, C and D.

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