Glucose Metabolism The standard potentials for the reduction of nicotinamide ade

Question

Glucose Metabolism The standard potentials for the reduction of nicotinamide adenine dinucleotide (NAD+) and oxaloacetate (reactants in the multistep metabolism of glucose) are as follows: NAD^+(aq) + 2 H^+(aq) + 2 e^- rightarrow NADH(aq) + H^+(aq) E degree = -0.320 V Oxaloacetate^2-(aq) + 2 H+(aq) + 2 e^- rightarrow malate^2-(aq) E degree = -0.166 V Calculate the standard potential for the following reaction: Oxaloacetate^2-(aq) + NADH(aq) + H^+(aq) rightarrow malate^-(aq) + NAD^+(aq) Calculate the equilibrium constant for the reaction at 298 K.

Explanation / Answer

a)   Standard potential Eo = -0.166 V - (-0.320 V) = 0.154 V

     Go = -RT InK     K = equilibrium constant

   Go = -nFEo        n = no of electrons transferred = 2

Then,

-RT InK = -nFEo

InK = nFEo/RT

K= e(nFEo/RT)

   = e^(2 x 96520 C/mol x 0.154 V /8.314 J/K/mol x 298 K)

= 162577

K = 162577

Therefore,

Equilibrium constant = 162577

  

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