NADH from the citric acid cycle binds at Complex I of the electron transport sys

Question

NADH from the citric acid cycle binds at Complex I of the electron transport system where it is oxidized back to NAD+. The NADH in glycolysis doesn't follow the same path, although it does possess energy due to being reduced by glyceraldehyde-3-phosphate dehydrogenase. What is the issue with NADH from glycolysis not being oxidized at Complex I of the electron transport system?

cytosolic NADH doesn't possess as much reductive potential as mitochondrial NADH cytosolic NADH undergoes oxidative phosphorylation within the nucleus NADH cannot diffuse across mitochondrial membranes cytosolic NADH oxidizes to FAD instead of NAD+ cytosolic NADH is different from mitochondrial NADH

Explanation / Answer

Biochemistry

NADH from the citric acid cycle binds at Complex I of the electron transport system where it is oxidized back to NAD+. The NADH in glycolysis doesn't follow the same path, although it does possess energy due to being reduced by glyceraldehyde-3-phosphate dehydrogenase. The issue with NADH from glycolysis not being oxidized at Complex I of the electron transport system is,

NADH cannot diffuse across mitochondrial membranes

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