12. For each of the following drugs, name the antilipe- mic category and briefly

Question

12. For each of the following drugs, name the antilipe- mic category and briefly describe how the drug lowers lipid levels. a. Gemfibrozil (Lopid) b. Niacin c. Lovastatin (Mevacor) d. Cholestyramine (Questran) 13. Mr. H. is a 46-year-old business executive who trav- els frequently. He is slightly overweight "from all that room service," but he did quit smoking 6 years ago. He has no history of coronary heart disease (CHD) or any family history of CHD. During a routine checkup, Mr. H. is found to have an LDL cholesterol level of 170 mg/dL. He says, "I'm a busy man! Just give me some pills. I've got a plane to catch!" Will the physician prescribe an antilipe mic for Mr. H.? Explain your answer. 14. Mrs. K. has been treated with cholestyramine (Questran) for type Ila hyperlipidemia for the past 2 months. She tells the nurse that she "can't stand being so irregular" and that she has developed an- other "embarrassing problem" as well. What does the nurse suspect is wrong with Mrs. K., and how can the nurse help her?

Explanation / Answer

Ans1:

a. Gemfibrozil: It belongs to fibrates family. It inhibits the lipolysis and subsequently decrease hepatic fatty acid uptake and also inhibits hepatic secretion of very low-density lipoprotein. Together these actions decrease serum VLDL levels and increase HDL cholesterol.

b. Niacin : belongs to like fibrate category of lipid-lowering agents. It reduces bad cholesterol, the exact mechanism of action is unknown.

c. Lovastatin: It belongs to statin family. It functions by inhibiting 3 hydroxy-3-methylglutaryl-coenzyme A reductase, which is an enzyme that catalyses the conversion of HMG-CoA to mevalonate. Mevalonate is a building block for cholesterol synthesis and lovastatin interferes with its production.

d. Cholestyramine: It is an adjuvant drug. It helps to treat primary hyperlipidemia. The exact mechanism is unknown. It also reduces bile obstruction.

Related Questions

Navigate

• Browse (All)
• Browse 1
• Subjects

---

---

Integrity-first tutoring: explanations and feedback only — we do not complete graded work. Learn more.