(17). This type of AED acts on the body through enhancing post-synaptic GABA rec

Question

(17). This type of AED acts on the body through enhancing post-synaptic GABA

receptor current, usefulness is limited by sedation and development of tolerance

a.) GABA reuptake inhibitor

b.) Na Channel Blocker

c.) Glutamate blocker

d.) GABA receptor agonist

(18.) This drug used for treating hypertension acts by blocking the conversion of angiotensin I to angiotensin II, a vasoconstrictor.

a.) beta adrenergic blocker

b.) calcium channel blocker

c) ACEi

d) digitalis

19. This drug used in treating angina acts by dilating the blood vessel.

a.) beta adrenergic blocker

b) nitroglycerin

c) calcium channel blocker

d) ACEi

(20.) This is a cardiac glycoside which affects the electrical and mechanical actions of the heart which increases contractility.

a.)  beta adrenergic blocker

b.) calcium channel blocker

c.) digitalis

d.) ACEi

Explanation / Answer

17.This type of AED acts on the body through enhancing post-synaptic GABA receptor current, usefulness is limited by sedation and development of tolerance

·       GABA receptor agonist

GABA is a neurotransmitter that inhibits the nerve transmissions in the brain and calms the nervous activities. Drugs that are GABA receptor agonist, facilitate the above described activity causing sedation.

18.This drug used for treating hypertension acts by blocking the conversion of angiotensin I to angiotensin II, a vasoconstrictor.

·       ACEi

This is a vasodilator. It inhibits (slows down) the activity of ACE (Angiotensin converting enzyme) and decreases the formation of angiotensin II. This result in dilation of blood vessels and thus reduces the blood pressure.

19.This drug used in treating angina acts by dilating the blood vessel.

a)   beta adrenergic blocker

b)   nitroglycerin

c)    calcium channel blocker

d)   ACEi

All the above mentioned drugs can be used to treat Angina.

·       Nitro-glycerine is often used to treat angina. These are vasodilators that relax the blood vessels and increase the blood flow to the heart muscles. The most common form are Nitroglucerine tablets that are taken sublingually for quick action.

20. This is a cardiac glycoside which affects the electrical and mechanical actions of the heart which increases contractility.

·       calcium channel blocker

Calcium channel blockers decrease the force of contractibility of heart muscle by reducing the electrical conduction in the heart. As a result the arteries dilate and reduce the blood pressure.

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