SCMED2020 Imr (1420) Semester 2, 2014 Which of the following statements about TH
ID: 126304 • Letter: S
Question
SCMED2020 Imr (1420) Semester 2, 2014 Which of the following statements about TH subsets is INCORRECT? A. B. C. 21. 1 cells secrete IFN-gamma, which can trigger B cell class switching to IgA TH2 TH cells are associated with allergic responses and produce IL-4 TH17 cells secrete IL-17 and are associated with infla responses D. IL-12 production by APCs can induce TH1 polarisation 22. Which of the following effector functions are best induced by Th2 cells? A. Fc-dependent phagocytosis B. Degranulation of Mast cells C. Activation of Complement proteins D. Recruitment of neutrophils 23. Which of the following statements about activated CD8 effector T cells is INCORRECT? A. They recognize antigens associated with MHC class I molecules B. They release perforin from their cytoplasmic granules C. They can directly recognise and lyse bacterial pathogens. D. They can potentially detect and kill virus infected cells Which of the following processes does NOT take place during B cell development? 24. A. Proliferation of immature B cells prior to immunoglobulin gene B. C. D. rearrangement Rearrangement of the Immunoglobulin heavy chain gene locus Expression of the Pre-BCR on the cell surface Positive selection mediated by interaction with stromal cells in the bone marroWExplanation / Answer
21.Ans : D
Interleukin 12 (IL-12) is produced by activated antigen-presenting cells (dendritic cells, macrophages). It promotes the development of Th1 responses and is a powerful inducer of IFN production by T and NK cells.
22.Ans : B
Degranulation of mast cells
23.Ans: B
24.Ans: B
Rearrangement immunoglobulin heavy chain gene locus - This is used to detect malignant disease condition
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