please answer question 1-5 1) Medication order: Mix 10 units in 250 mL D5W. What

Question

please answer question 1-5

1) Medication order: Mix 10 units in 250 mL D5W.
What is the concentration in units per mL?

2) Medication order: Mix 250 mg in 250 mL D5W.
What is the concentration in milligrams per mL?

3) Mix 500 mcg in 1000 mL NS.
What is the concentration in micrograms per mL?

4) Mix 10 units of oxytocin in 1000 mL NS.
Start infusion at 25 mL/hr.
Increase by 5 mL/hr every 10 minutes until uterine contractions are 2 to 3 minutes apart.
Do not exceed 44 milliunits/min.
Maintain total IV fluid volume at 100 mL/hr.

How many milliunits per hour will be delivered?

5) Mix 10 units of oxytocin in 1000 mL NS.
Start infusion at 25 mL/hr.
Increase by 5 mL/hr every 10 minutes until uterine contractions are 2 to 3 minutes apart.
Do not exceed 44 milliunits/min.
Maintain total IV fluid volume at 100 mL/hr.
You have calculated that 250 milliunits/hr will be delivered.

How many milliunits per minute will be delivered?

Explanation / Answer

1) Medication order: Mix 10 units in 250 mL D5W.
What is the concentration of units per mL?

Available unit at hand - 10 units

Total volume of dextrose solution - 250 ml

To calculate unit /ml, use the below formula   

Amount of Drug / Amount of Fluid (mL) = Amount of Drug in 1 mL

ie 10 units / 250 ml x 1 ml  

= 0.04 unit per ml

so the unit present in each ml is 0.04 unit

2) Medication order: Mix 250 mg in 250 mL D5W.
What is the concentration in milligrams per mL?

the available amount of drug at hand = 250 mg

Total volume of D5W = 250 ml

To find mg/ ml, Calulate concentration of a solution describes the mass of the solute (amount of drug) divided by the volume of solution.

ie, Amount of drug / Volume of solution

250 mg / 250 ml = 1 mg

So the concentration in milligrams per ml = 1mg/ml

3. Mix 500 mcg in 1000 mL NS.
What is the concentration in micrograms per mL?

Available drug by hand - 500 mcg

Total volume of fluids = 1000 ml

first, convert microgram( mcg) to the milligram( mg )

to convert microgram to milligram, we need to divide the value by 1000.

so 500 / 1000 = .5 mg

Now to get the mg/ml, use the formula -The concentration of a solution describes the mass of the solute (amount of drug) divided by the volume of solution

ie Amount of drug/volume of solution

0.5 mg / 1000 ml

= 0.0005 mg

So the concentration in milligrams per ml is 0.0005mg / ml

4. Mix 10 units of oxytocin in 1000 mL NS. Start infusion at 25 mL/hr. Increase by 5 mL/hr every 10 minutes until uterine contractions are 2 to 3 minutes apart. Do not exceed 44 milliunits/min.Maintain total IV fluid volume at 100 mL/hr.
How many milliunits per hour will be delivered?

the available dose of oxytocin =10 unit

the total volume of Ns fluid = 1000 ml

so, In every 1 ml of Normal saline contains, 10/1000 = 0.01 unit of oxytocin

Now, in the at first 10 minutes, the rate of flow is 25 ml/hr so to calculate the dose transfused for the first 10 minutes, calculate the total volume infused multiplied by the drug concentration in one ml.

here the total volume infused in 10 minutes is 25 ml, so

25 ml x 0.01 unit = 0.25 unit of oxytocin

so, in the first 10-minute patient will receive 0.25 unit of oxytocin

next 10-20 minute the flow rate to 30 ml per hour, since in every 10 minutes 5 ml/hour flowrate will increase

so 30ml x 0.01 unit = 0.3unit of oxytocin/hr

so the patient will receive 0.3 unit of oxytocin

next 20- 30 minutes, the flow rate will be 35 ml/hr

so 35ml x 0.01 unit = 0.32 unit of oxytocin /hr

next 30-40 minutes, the flow rate will be 40 ml/ hr

so 40ml x 0.01 unit = 0. 4 unit /hr

next 40-50 minutes, the flow rate will be 45 ml/hr

so 45ml x 0.01 unit = 0.45 unit/hr

next 50 - 60 minutes, the flow rates will be 50 ml /hr

50ml x 0.01 unit = 0.5 unit/hr

For one hour total unit delivered to the patient is = 0.25+0.3+0.32+0.4+0.45+0.5

= 2.22 units / hour

5. Mix 10 units of oxytocin in 1000 mL NS. Start infusion at 25 mL/hr. Increase by 5 mL/hr every 10 minutes until uterine contractions are 2 to 3 minutes apart. Do not exceed 44 milliunits/min. Maintain total IV fluid volume at 100 mL/hr. You have calculated that 250 milliunits/hr will be delivered. How many milliunits per minute will be delivered?

To calculate the unit /minutes, divide the volume or dose by 60

from the 4 the answer to the question, we have the calculated the total units delivered to the patient per hour  

ie 2.22 units / hr

to convert hours to minute divide the dose with 60

so in minutes it will be

2.22 unit / 60 = 0.037 units / minutes

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