A 21-year-old woman presents with a 3-month history of malaise, joint pain, weig

Question

A 21-year-old woman presents with a 3-month history of malaise, joint pain, weight loss, and sporadic fever. Her temperature is 38°C (101°F). The serum antinuclear antibody (ANA) test is positive (1:640). Corticosteroids are prescribed to suppress the patient's immune system. Death of post-thymic lymphocytes induced by corticosteroid therapy is characterized by fragmentation of DNA, which can be detected by gel electrophoresis in the form of a “ladder.” This finding represents sequential cleavage of which of the following cellular components?
Question options:

A) Centrosomes
B) Kinetochores
C) Nucleoli
D) Nucleosomes

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Explanation / Answer

The resulting structure comes from the cleavage of nucleosomes. Nucleosomes are a structural unit of a eukaryotic chromosome. They consist of a length of DNA coiled around histone cores.

Hence, the correct option is (D) nucleosomes.

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